They are genetically altered men with one thing in common: They have all been beaten by Spider-Man. Now, the Green Goblin, Doctor Octopus, the Sandman, Electro and Kraven the Hunter are being held together in a S.H.I.E.L.D. containment center. But they will not be held for long. What happens when five of the world's worst criminals escape and join forces? Who will they target as the sixth member of their deadly alliance? Spider-Man must do whatever it takes to make sure his family and friends are safe. But even with the help of the Ultimates, will that be enough? Collects ULTIMATE SPIDER-MAN #46 and ULTIMATE SIX #1-7. Written by BRIAN MICHAEL BENDIS; Penciled by TREVOR HAIRSINE, MARK BAGLEY and JOE QUESADA; Cover by JOHN CASSADAY. 208 PGS./ ALL AGES