The X-Men head west, founding a new home for all mutants in San Francisco! But they soon find themselves tangling with Magneto, Sentinels and the new Hellfire Cult! Then, heartsick over losing Kitty Pryde, Colossus looks for something to stop his pain - and finds a nightmare from his past! Plus: Angel and the Beast gather the most unique minds on Earth to jumpstart the mutant race, even as Emma Frost forges a dark alliance. Finally, who are the Sisterhood? How can they be led by Cyclops' late wife, Madelyne Pryor? And why is Psylocke on their side?! Things get ugly for the X-Men as Eisner Award-winner Matt Fraction turns up the heat! Collecting UNCANNY X-MEN (1963) #500-511, UNCANNY X-MEN ANNUAL (2006) #2, and material from X-MEN UNLIMITED (2004) #9 and X-MEN: DIVIDED WE STAND #1.